SOURCE-GROUNDED OPERATIONS TOOL
Supplement Ecommerce Compliance Matrix
A working map of the product, listing, advertising, creator, payment, and operational controls supplement brands should verify across major channels.
Last source review: July 27, 2026. Platform policies change. Use the linked primary source and the requirements shown in your account before acting.
| Channel | Current source | Primary release controls | Brand responsibility |
|---|---|---|---|
| Amazon | Dietary supplement verification announcement | ASIN file, Account Health and Manage Your Compliance workflow, approved-provider process, catalog and creative QA, case log | Accurate product, documentation, label, substantiation, and qualified review |
| Shopify | Shopify Payments eligibility | Merchant, product, payment, market, checkout, recurring-purchase, privacy, and customer-service review | Product and business eligibility, lawful operation, accurate claims, and clear terms |
| TikTok Shop | Dietary Supplements Requirements | Category eligibility, product file, listing, creator guardrails, disclosures, samples, fulfillment, returns, and account monitoring | Product records, approved messaging, partner oversight, and platform response |
| Unapproved substances policy | SKU and market policy profile, feed, Merchant Center, ad, creative, landing page, conversion, and appeal record | Eligible product and market, accurate destination, substantiation, and qualified review | |
| Meta | Advertising Standards | Product, claims, implied message, personal-attribute, audience, creative, destination, data, and incident review | Accurate product and evidence, appropriate data use, and approved messaging |
| Creators and affiliates | FTC Disclosures 101 | Material-connection disclosure, product brief, claims guardrails, approval, live monitoring, and correction | Truthful endorsement program, adequate support, and partner oversight |
| Cross-channel claims | FTC Health Products Compliance Guidance | Express and implied message review, evidence register, clear qualifications, testimonials, and release record | Truthful and supported advertising and qualified review |
| Label foundation | FDA Dietary Supplement Labeling Guide | Controlled label version, product identity, facts, ingredients, directions, warnings, business information, and channel reconciliation | Product-specific labeling and legal responsibility |
Scope: This matrix is an ecommerce operating aid, not medical or legal advice and not a complete statement of requirements. It does not approve any product, label, claim, ad, seller, or account.
Turn the matrix into a release system
Control the product
Version the product, label, evidence, package, claims, channel IDs, and effective dates.
Control the release
Check the channel, market, asset, destination, owner, inventory, and approval before publishing.
Control the incident
Preserve the notice and asset, diagnose the exact issue, respond through the official path, and update prevention.